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Red blood cell storage lesion: causes and potential clinical consequences
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
Red blood cell metabolism in vivo and in vitro
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …
Erythrocyte metabolism
Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …
richness and complexity. We have manually collected and connected the available …
Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine
Transfusion of red blood cells (RBCs) is one of the most valuable and widespread
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …
Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study
Genetic polymorphisms in blood donors may contribute to donor-specific differences in the
survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic …
survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic …
[HTML][HTML] Oxidative stress in β-thalassaemia and sickle cell disease
Sickle cell disease and β-thalassaemia are inherited haemoglobinopathies resulting in
structural and quantitative changes in the β-globin chain. These changes lead to instability …
structural and quantitative changes in the β-globin chain. These changes lead to instability …
Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk
Malaria parasites invade red blood cells (RBCs), consume copious amounts of hemoglobin,
and severely disrupt iron regulation in humans. Anemia often accompanies malaria disease; …
and severely disrupt iron regulation in humans. Anemia often accompanies malaria disease; …
Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress
Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal,
splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo …
splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo …
Iron chelators for the treatment of cancer
The study of iron chelators as anti-tumor agents is still in its infancy. Iron is important for
cellular proliferation and this is demonstrated by observations that iron-depletion results in …
cellular proliferation and this is demonstrated by observations that iron-depletion results in …
Inborn defects in the antioxidant systems of human red blood cells
R Van Zwieten, AJ Verhoeven, D Roos - Free Radical Biology and …, 2014 - Elsevier
Red blood cells (RBCs) contain large amounts of iron and operate in highly oxygenated
tissues. As a result, these cells encounter a continuous oxidative stress. Protective …
tissues. As a result, these cells encounter a continuous oxidative stress. Protective …