An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

In the non‐amyloidogenic pathway, the Alzheimer's amyloid precursor protein (APP) is
cleaved within the amyloid‐β domain by α‐secretase precluding deposition of intact amyloid …

This article is part of a Special Issue" Hormones & Neurotrauma". Age-related loss of sex
steroid hormones is a established risk factor for the development of Alzheimer's disease …

Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …

In addition to its role as a sex hormone, oestrogen affects the structure and function of the
nervous system. Oestrogen receptors are expressed in brain regions that are involved in sex …

A promising strategy to delay and perhaps prevent Alzheimer's disease (AD) is to identify the
age-related changes that put the brain at risk for the disease. A significant normal age …

The beta amyloid (Aβ) protein is a key molecule in the pathogenesis of Alzheimer's disease
(AD). The tendency of the Aβ peptide to aggregate, its reported neurotoxicity, and genetic …

Testosterone–the gonadal sex steroid hormone plays an important role in the central
nervous system (CNS) development. One of the less known testosterone actions is …