Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

During mating, males transfer seminal proteins and peptides, along with sperm, to their
mates. In Drosophila melanogaster, seminal proteins made in the male's accessory gland …

The functions of serotonin have been assigned through serotonin-receptor-specific drugs
and mutants,; however, because a constellation of receptors remains when a single receptor …

Eukaryotic gene expression is mediated by compact cis-regulatory modules, or enhancers,
which are bound by specific sets of transcription factors. The combinatorial interaction of …

The growth and behavior of higher organisms depend on the accurate perception and
integration of sensory stimuli by the nervous system. We show that defects in sensory …

Four biogenic amines: octopamine, tyramine, dopamine and serotonin act in C. elegans to
modulate behavior in response to changing environmental cues. These neurotransmitters …

As the demographics of the modern world skew older, understanding and mitigating the
effects of aging is increasingly important within biomedical research. Recent studies in …

Small-molecule inhibitors of protein function are powerful tools for biological analysis and
can lead to the development of new drugs. However, a major bottleneck in generating useful …

Background Caenorhabditis elegans locomotion is a simple behavior that has been widely
used to dissect genetic components of behavior, synaptic transmission, and muscle function …

We show that serotonin inhibits synaptic transmission at C. elegans neuromuscular
junctions, and we describe a signaling pathway that mediates this effect. Release of …