Human carcinomas frequently express high levels of receptors in the EGF receptor family,
and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely …

Abstract Dent, P., Yacoub, A., Contessa, J., Caron, R., Amorino, G., Valerie, K., Hagan, MP,
Grant, S. and Schmidt-Ullrich, R. Stress and Radiation-Induced Activation of Multiple …

NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to
HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream …

We used whole-genome and transcriptome sequencing to identify clinically actionable
genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC) …

We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)‐
related peptides in cell lines naturally expressing the four ErbB receptors. Down‐regulation …

The ErbB family includes four homologous transmembrane tyrosine kinases. Whereas ErbB-
1 binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu …

The ErbB family includes two receptors, ErbB‐1 and ErbB‐3, that respectively bind to
epidermal growth factor and Neu differentiation factor, and an orphan receptor, ErbB‐2 …

The erbB-2/HER2 oncogene is overexpressed in a significant fraction of human carcinomas
of the breast, ovary, and lung in a manner that correlates with poor prognosis. Although the …

Overexpression of the erbB‐2 gene contributes to aggressive behavior of various human
adenocarcinomas, including breast cancer, through an unknown molecular mechanism. The …

ErbB receptor activation is a complex process and is dependent upon the type and number
of receptors expressed on a given cell. Previous studies with defined combinations of ErbB …