Hyperferritinaemia is a common laboratory finding that is often associated with metabolic
dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron …

Emerging scientific evidence has disclosed unsuspected influences between iron
metabolism and type 2 diabetes. The relationship is bi-directional—iron affects glucose …

ContextType 2 diabetes is a common manifestation of hemochromatosis, a disease of iron
overload. However, it is not clear whether higher iron stores predict the development of type …

Nonalcoholic fatty liver disease occurs most frequently in obese middle-aged women. It also
may occur, however, in children and normal-weight men with normal glucose and lipid …

The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general
population, as is detected in about one third of patients with nonalcoholic fatty liver disease …

Dietary iron assimilation is critical for health and essential to prevent iron-deficient states
and related comorbidities, such as anemia. The bioavailability of iron is generally low, while …

Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of
normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic …

OBJECTIVE The bidirectional relationship between iron metabolism and glucose
homeostasis is increasingly recognized. Several pathways of iron metabolism are modified …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of adults and 20% of
children in the United States. Nonalcoholic steatohepatitis (NASH) is its most severe …