Laser speckle contrast imaging: theory, instrumentation and applications

J Senarathna, A Rege, N Li… - IEEE reviews in …, 2013 - ieeexplore.ieee.org
Laser Speckle Contrast Imaging (LSCI) is a wide field of view, non scanning optical
technique for observing blood flow. Speckles are produced when coherent light scattered …

Expanding applications, accuracy, and interpretation of laser speckle contrast imaging of cerebral blood flow

SMS Kazmi, LM Richards, CJ Schrandt… - Journal of Cerebral …, 2015 - journals.sagepub.com
Laser speckle contrast imaging (LSCI) provides a rapid characterization of cortical flow
dynamics for functional monitoring of the microcirculation. The technique stems from …

Real-time imaging of brain activity in freely moving rats using functional ultrasound

A Urban, C Dussaux, G Martel, C Brunner, E Mace… - Nature …, 2015 - nature.com
Innovative imaging methods help to investigate the complex relationship between brain
activity and behavior in freely moving animals. Functional ultrasound (fUS) is an imaging …

A miniature multi-contrast microscope for functional imaging in freely behaving animals

J Senarathna, H Yu, C Deng, AL Zou, JB Issa… - Nature …, 2019 - nature.com
Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are
critical to brain function, and dysregulated in neuropathologies such as brain tumors …

Neurovascular coupling: in vivo optical techniques for functional brain imaging

LD Liao, V Tsytsarev, I Delgado-Martínez, ML Li… - Biomedical engineering …, 2013 - Springer
Optical imaging techniques reflect different biochemical processes in the brain, which is
closely related with neural activity. Scientists and clinicians employ a variety of optical …

Quantitative blood flow estimation in vivo by optical speckle image velocimetry

MM Qureshi, Y Liu, KD Mac, M Kim, AM Safi, E Chung - Optica, 2021 - opg.optica.org
Speckle-based methods are popular non-invasive, label-free full-field optical techniques for
imaging blood flow maps at single vessel resolution with a high temporal resolution …

Dual-display laparoscopic laser speckle contrast imaging for real-time surgical assistance

C Zheng, LW Lau, J Cha - Biomedical Optics Express, 2018 - opg.optica.org
Laser speckle contrast imaging (LSCI) utilizes the speckle pattern of a laser to determine the
blood flow in tissues. The current approaches for its use in a clinical setting require a camera …

Location matters: navigating regional heterogeneity of the neurovascular unit

LP Bernier, C Brunner, A Cottarelli… - Frontiers in Cellular …, 2021 - frontiersin.org
The neurovascular unit (NVU) of the brain is composed of multiple cell types that act
synergistically to modify blood flow to locally match the energy demand of neural activity, as …

Wearable optical resolution photoacoustic microscopy

Q Chen, H **e, L ** - Journal of biophotonics, 2019 - Wiley Online Library
Optical resolution photoacoustic microscopy (ORPAM) is an emerging imaging technique,
which has been extensively used to study various brain activities and disorders of the …

Detachable head-mounted photoacoustic microscope in freely moving mice

H Guo, Q Chen, W Qin, W Qi, L ** - Optics letters, 2021 - opg.optica.org
Optical resolution photoacoustic microscopy (ORPAM) is a promising tool for investigating
anatomical and functional dynamics in cerebral cortex. However, observation in freely …