The Evolutionary Interplay of Somatic and Germline Mutation Rates
Novel sequencing technologies are making it increasingly possible to measure the mutation
rates of somatic cell lineages. Accurate germline mutation rate measurement technologies …
rates of somatic cell lineages. Accurate germline mutation rate measurement technologies …
The mutagenic consequences of defective DNA repair
E Németh, D Szüts - DNA repair, 2024 - Elsevier
Multiple separate repair mechanisms safeguard the genome against various types of DNA
damage, and their failure can increase the rate of spontaneous mutagenesis. The …
damage, and their failure can increase the rate of spontaneous mutagenesis. The …
An expanding universe of mutational signatures and its rapid evolution in single-stranded RNA viruses
Y Yang, X Zhang, T Chen, F Wu… - Molecular Biology …, 2025 - academic.oup.com
The study of mutational processes in somatic genomes has gained recent momentum,
uncovering a wide array of endogenous and exogenous factors associated with somatic …
uncovering a wide array of endogenous and exogenous factors associated with somatic …
Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes
Mitochondrial DNA (mtDNA) mutagenesis remains poorly understood despite its crucial role
in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive …
in disease, aging, and evolutionary tracing. In this study, we reconstructed a comprehensive …
NeMu: a comprehensive pipeline for accurate reconstruction of neutral mutation spectra from evolutionary data
The recognized importance of mutational spectra in molecular evolution is yet to be fully
exploited beyond human cancer studies and model organisms. The wealth of intraspecific …
exploited beyond human cancer studies and model organisms. The wealth of intraspecific …
k-mer-based approaches to bridging pangenomics and population genetics
MD Roberts, O Davis, EB Josephs… - ar** phenotypic differences between
species, little is currently known about the evolution of germline mutation spectra across …
species, little is currently known about the evolution of germline mutation spectra across …
Low mutation rate but high male-bias in the germline of a short-lived opossum
Age and sex have been found to be important determinants of the mutation rate per
generation in mammals, but the mechanisms underlying these factors are still unclear. One …
generation in mammals, but the mechanisms underlying these factors are still unclear. One …
The evolution of mutation rates in the light of development and cell-lineage selection
Mutation rates drive the pace and potential of evolutionary change. However, to better
understand the evolutionary implications of mutation rates, there is a need to uncover the …
understand the evolutionary implications of mutation rates, there is a need to uncover the …
Robust inference of historical human generation times
Abstract raise concerns about our recent estimates of historical human generation times,
concluding that our results were “predominantly driven by nonbiological artifacts.” While we …
concluding that our results were “predominantly driven by nonbiological artifacts.” While we …