This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Elevated plasma bilirubin levels are a frequent clinical finding. It can be secondary to
alterations in any stage of its metabolism:(a) excess bilirubin production (ie, pathologic …

Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …

The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …

The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Background: Multiple pharmacogenomic studies have identified the synonymous genomic
variant rs7853758 (G> A, L461L) and the intronic variant rs885004 in SLC28A3 (solute …