Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Cardiogenic shock is a primary cardiac disorder that results in both clinical and biochemical
evidence of tissue hypoperfusion and can lead to multi‐organ failure and death depending …

Introduction: In the 20 years since its introduction to the palette of intravenous hemodynamic
therapies, the inodilator levosimendan has established itself as a valuable asset for the …

Mechanism-based therapy centred on the molecular understanding of disease-causing
pathways in a given patient is still the exception rather than the rule in medicine, even in …

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Dilated cardiomyopathy (DCM) is a major risk factor for heart failure and is associated with
the development of life-threatening cardiac arrhythmias. Using a patient-specific induced …

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with an
increased morbidity and mortality. There is clinical evidence that an increasing number of …

Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising
strategy to accelerate drug discovery and development. This approach involves identifying …

Levosimendan is a distinctive inodilator combing calcium sensitization, phosphodiesterase
inhibition and vasodilating properties through the opening of adenosine triphosphate …

Background Vein of Galen aneurysmal malformation (VGAM) is a rare cerebral vascular
malformation associated with significant morbidity and mortality. Newborns with VGAM …