This review provides a detailed look at the attributes and immunologic mechanisms of
plasmid DNA vaccines and their utility as laboratory tools as well as potential human …

Adjuvant design has historically had a touch of alchemy at its heart due to its reliance on the
complex biology of innate immune activation. However, a new mechanistic understanding of …

CD8+ T‐cell responses are critical in the immunological control of tumours and infectious
diseases. To prime CD8+ T cells against these cell‐associated antigens, exogenous …

In the years following the publication of the initial in vivo demonstration of the ability of
plasmid DNA to generate protective immune responses, DNA vaccines have entered into a …

Current vaccine and immunotherapy technology faces ongoing challenges in both efficacy
and practicality: many chronic diseases cannot yet be addressed by vaccination, and …

New generation vaccines, particularly those based on recombinant proteins and DNA, are
likely to be less reactogenic than traditional vaccines, but are also less immunogenic …

The translocation of particulate matter across the gastrointestinal tract is now a well
documented phenomenon offering new potential for the delivery of drugs with poor …

Efforts to make vaccines against infectious diseases as well as immunotherapies for cancer,
autoimmune diseases and allergy have utilized a variety of heterologous expression …

Gene delivery holds great potential for the treatment of many different diseases. Vaccination
with DNA holds particular promise, and may provide a solution to many technical challenges …

Pulmonary gene delivery is thought to play an important role in treating genetically related
diseases and may induce immunity towards pathogens entering the body via the airways. In …