Importance of prophages to evolution and virulence of bacterial pathogens

LC Fortier, O Sekulovic - Virulence, 2013 - Taylor & Francis
Bacteriophages, or simply phages, are viruses infecting bacteria. With an estimated 1031
particles in the biosphere, phages outnumber bacteria by a factor of at least 10 and not …

The disparate effects of bacteriophages on antibiotic-resistant bacteria

C Torres-Barceló - Emerging microbes & infections, 2018 - Taylor & Francis
Faced with the crisis of multidrug-resistant bacteria, bacteriophages, viruses that infect and
replicate within bacteria, have been reported to have both beneficial and detrimental effects …

In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

K Selle, JR Fletcher, H Tuson, DS Schmitt, L McMillan… - MBio, 2020 - Am Soc Microbiol
Clostridioides difficile is an important nosocomial pathogen that causes approximately
500,000 cases of C. difficile infection (CDI) and 29,000 deaths annually in the United States …

Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo

JY Nale, J Spencer, KR Hargreaves… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The microbiome dysbiosis caused by antibiotic treatment has been associated with both
susceptibility to and relapse of Clostridium difficile infection (CDI). Bacteriophage (phage) …

Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy

AM Segall, DR Roach, SA Strathdee - Current opinion in microbiology, 2019 - Elsevier
Increasingly, clinical infections are becoming recalcitrant or completely resistant to
antibiotics treatment and multidrug resistance is rising alarmingly. Patients suffering from …

Horizontal gene transfer in human pathogens

M Juhas - Critical reviews in microbiology, 2015 - Taylor & Francis
Horizontal gene transfer has a tremendous impact on the genome plasticity, adaptation and
evolution of bacteria. Horizontally transferred mobile genetic elements are involved in the …

The role of temperate bacteriophages in bacterial infection

EV Davies, C Winstanley, JL Fothergill… - FEMS microbiology …, 2016 - academic.oup.com
Bacteriophages are viruses that infect bacteria. There are an estimated 1031 phage on the
planet, making them the most abundant form of life. We are rapidly approaching the …

Bacteriophages: an underestimated role in human and animal health?

M De Paepe, M Leclerc, CR Tinsley… - Frontiers in cellular and …, 2014 - frontiersin.org
Metagenomic approaches applied to viruses have highlighted their prevalence in almost all
microbial ecosystems investigated. In all ecosystems, notably those associated with humans …

[BOK][B] The comprehensive sourcebook of bacterial protein toxins

JE Alouf, D Ladant, MR Popoff - 2005 - books.google.com
This book describes the major achievements and discoveries relevant to bacterial protein
toxins since the turn of the new century illustrated by the discovery of more than fifty novel …

Prophage activation in the intestine: insights into functions and possible applications

J Hu, H Ye, S Wang, J Wang, D Han - Frontiers in Microbiology, 2021 - frontiersin.org
Prophage activation in intestinal environments has been frequently reported to affect host
adaptability, pathogen virulence, gut bacterial community composition, and intestinal health …