Self-assembling peptide hydrogels as functional tools to tackle intervertebral disc degeneration
Low back pain (LBP), caused by intervertebral disc (IVD) degeneration, is a major
contributor to global disability. In its healthy state, the IVD is a tough and well-hydrated …
contributor to global disability. In its healthy state, the IVD is a tough and well-hydrated …
Design requirements for annulus fibrosus repair: review of forces, displacements, and material properties of the intervertebral disk and a summary of candidate …
RG Long, OM Torre, WW Hom… - Journal of …, 2016 - asmedigitalcollection.asme.org
There is currently a lack of clinically available solutions to restore functionality to the
intervertebral disk (IVD) following herniation injury to the annulus fibrosus (AF) …
intervertebral disk (IVD) following herniation injury to the annulus fibrosus (AF) …
[HTML][HTML] Injectable disc-derived ECM hydrogel functionalised with chondroitin sulfate for intervertebral disc regeneration
Low back pain resulting from intervertebral disc (IVD) degeneration is a significant
socioeconomic burden. The main effect of the degeneration process involves the alteration …
socioeconomic burden. The main effect of the degeneration process involves the alteration …
Intervertebral disc swelling maintains strain homeostasis throughout the annulus fibrosus: a finite element analysis of healthy and degenerated discs
Tissues in the intervertebral disc have a large capacity to absorb water, partially due to the
high glycosaminoglycan (GAG) content, which decreases linearly from the nucleus pulposus …
high glycosaminoglycan (GAG) content, which decreases linearly from the nucleus pulposus …
Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear …
Finite element (FE) models are advantageous in the study of intervertebral disc mechanics
as the stress–strain distributions can be determined throughout the tissue and the applied …
as the stress–strain distributions can be determined throughout the tissue and the applied …
Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics
Low back pain is a leading cause of disability worldwide and the second most common
cause of physician visits. There are many causes of back pain, and among them, disc …
cause of physician visits. There are many causes of back pain, and among them, disc …
Mechanical characterization and design of biomaterials for nucleus pulposus replacement and regeneration
Biomaterials for nucleus pulposus (NP) replacement and regeneration have great potential
to restore normal biomechanics in degenerated intervertebral discs following nucleotomy …
to restore normal biomechanics in degenerated intervertebral discs following nucleotomy …
Human cartilage endplate permeability varies with degeneration and intervertebral disc site
Despite the critical functions the human cartilage endplate (CEP) plays in the intervertebral
disc, little is known about its structural and mechanical properties and their changes with …
disc, little is known about its structural and mechanical properties and their changes with …
Importance of matrix cues on intervertebral disc development, degeneration, and regeneration
Back pain is one of the leading causes of disability worldwide and is frequently caused by
degeneration of the intervertebral discs. The discs' development, homeostasis, and …
degeneration of the intervertebral discs. The discs' development, homeostasis, and …
Effect of hydration on healthy intervertebral disk mechanical stiffness
The intervertebral disk has an excellent swelling capacity to absorb water, which is thought
to be largely due to the high proteoglycan composition. Injury, aging, degeneration, and …
to be largely due to the high proteoglycan composition. Injury, aging, degeneration, and …