The cytokine network involved in the host immune response to periodontitis

W Pan, Q Wang, Q Chen - International journal of oral science, 2019 - nature.com
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

Rhinitis associated with asthma is distinct from rhinitis alone: the ARIA‐MeDALL hypothesis

J Bousquet, E Melén, T Haahtela, GH Koppelman… - Allergy, 2023 - Wiley Online Library
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …

Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation

LP Bharath, M Agrawal, G McCambridge, DA Nicholas… - Cell metabolism, 2020 - cell.com
Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …

[HTML][HTML] Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases

K Bunte, T Beikler - International journal of molecular sciences, 2019 - mdpi.com
Innate immunity represents the semi-specific first line of defense and provides the initial host
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …

The impact of diabetes on periodontal diseases

DT Graves, Z Ding, Y Yang - Periodontology 2000, 2020 - Wiley Online Library
The susceptibility and severity of periodontal diseases is made more severe by diabetes,
with the impact on the disease process inversely proportional to the level of glycemic control …

Immune mechanisms in oral lichen planus

A El‐Howati, MH Thornhill, HE Colley… - Oral diseases, 2023 - Wiley Online Library
Oral lichen planus (OLP) is a T cell‐mediated inflammatory disease of the oral mucosa that
has been extensively researched over many years but as yet the mechanisms of …

[HTML][HTML] An overview of physical, microbiological and immune barriers of oral mucosa

S Şenel - International journal of molecular sciences, 2021 - mdpi.com
The oral mucosa, which is the lining tissue of the oral cavity, is a gateway to the body and it
offers first-line protection against potential pathogens, exogenous chemicals, airborne …

The oral microbiota is modified by systemic diseases

DT Graves, JD Corrêa, TA Silva - Journal of dental research, 2019 - journals.sagepub.com
Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth
surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes …

Frailty, aging, and periodontal disease: Basic biologic considerations

D Clark, E Kotronia, SE Ramsay - Periodontology 2000, 2021 - Wiley Online Library
Aging is associated with the development of disease. Periodontal disease is one of the
many diseases and conditions that increase in prevalence with age. In addition to the …

A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans

N Dutzan, T Kajikawa, L Abusleme… - Science translational …, 2018 - science.org
Periodontitis is one of the most common human inflammatory diseases, yet the mechanisms
that drive immunopathology and could be therapeutically targeted are not well defined …