Microbiota medicine: towards clinical revolution

P Gebrayel, C Nicco, S Al Khodor, J Bilinski… - Journal of translational …, 2022 - Springer
The human gastrointestinal tract is inhabited by the largest microbial community within the
human body consisting of trillions of microbes called gut microbiota. The normal flora is the …

Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy

AM Thomas, M Fidelle, B Routy, G Kroemer… - Nature reviews Clinical …, 2023 - nature.com
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …

CheckM2: a rapid, scalable and accurate tool for assessing microbial genome quality using machine learning

A Chklovski, DH Parks, BJ Woodcroft, GW Tyson - Nature methods, 2023 - nature.com
Advances in sequencing technologies and bioinformatics tools have dramatically increased
the recovery rate of microbial genomes from metagenomic data. Assessing the quality of …

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

C Li, M Stražar, AMT Mohamed, JA Pacheco… - Cell, 2024 - cell.com
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

Dysbiosis of human gut microbiome in young-onset colorectal cancer

Y Yang, L Du, D Shi, C Kong, J Liu, G Liu, X Li… - Nature …, 2021 - nature.com
The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant
knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients …

Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide

HC Lai, TL Lin, TW Chen, YL Kuo, CJ Chang, TR Wu… - Gut, 2022 - gut.bmj.com
Objective Chronic obstructive pulmonary disease (COPD) is a global disease characterised
by chronic obstruction of lung airflow interfering with normal breathing. Although the …

The gut–airway microbiome axis in health and respiratory diseases

M Özçam, SV Lynch - Nature Reviews Microbiology, 2024 - nature.com
Communication between the gut and remote organs, such as the brain or the cardiovascular
system, has been well established and recent studies provide evidence for a potential …

[HTML][HTML] Gut microbiota: A new insight into lung diseases

PJ Ma, MM Wang, Y Wang - Biomedicine & pharmacotherapy, 2022 - Elsevier
The human gut microbiota is a complex ecosystem involved in the metabolism, immunity,
and health of the host. The microbiome plays a key role in the development of the host's …

The bidirectional gut–lung axis in chronic obstructive pulmonary disease

L Wang, Y Cai, J Garssen, PAJ Henricks… - American journal of …, 2023 - atsjournals.org
Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is
associated with the incidence of changes in intestinal health. Cigarette smoking, as one of …

[HTML][HTML] Chronic obstructive pulmonary disease: epidemiology, biomarkers, and paving the way to lung cancer

K Szalontai, N Gémes, J Furák, T Varga… - Journal of clinical …, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …