Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

The anaplastic lymphoma kinase (ALK) receptor is a membrane-bound tyrosine kinase. The
pathogenesis of several cancers is closely related to aberrant forms of ALK or aberrant ALK …

There is considerable inter-individual variability in susceptibility to weight gain despite an
equally obesogenic environment in large parts of the world. Whereas many studies have …

Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …

Neurotrophic growth factors were originally characterized for their support in neuronal
differentiation, outgrowth, and survival during development. However, it has been …

Anaplastic lymphoma kinase (Alk) is an evolutionary conserved receptor tyrosine kinase
belonging to the insulin receptor superfamily. In addition to its well-studied role in cancer …

This review commemorates the 10-year anniversary of the discovery of physiological ligands
Augα (Augmentor α; ALKAL2; Fam150b) and Augβ (Augmentor β; ALKAL1; Fam150a) for …

Proteinopathy in neurodegenerative diseases is typically characterized by deteriorating
activity of specific protein aggregates. In tauopathies, including Alzheimer's disease (AD) …

A growing number of studies implicate alterations in glutamatergic signaling within the
reward circuitry of the brain during alcohol abuse and dependence. A key integrator of …

Alcohol use disorder (AUD) has a complex pathogenesis, making it a difficult disorder to
treat. Identifying relevant signaling pathways in the brain may be useful for finding new …