Reactive oxygen species (ROS) play an important role in physiological and pathological
processes. In recent years, a feed-forward regulation of the ROS sources has been reported …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

Background—Inflammatory mediators that originate in vascular and extravascular tissues
promote coronary lesion formation. Adipose tissue may function as an endocrine organ that …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Incubation of endothelial cells in vitro with high concentrations of glucose activates protein
kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as …

1. Background: the concept of 'endothelial dysfunc- deficiency of either the substrate for the
enzyme NO tion' synthase or one of its critical co-factors. Alterations of endothelial cell …

The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …

Conventional views of the tunica adventitia as a poorly organized layer of vessel wall
composed of fibroblasts, connective tissue, and perivascular nerves are undergoing …

We previously reported enhanced expression of the p67 phox and gp91 phox components
of NAD (P) H oxidase in angiotensin (Ang) II–induced hypertension, suggesting de novo …