The dynamic lung microbiome in health and disease

JG Natalini, S Singh, LN Segal - Nature Reviews Microbiology, 2023 - nature.com
New methods and technologies within the field of lung biology are beginning to shed new
light into the microbial world of the respiratory tract. Long considered to be a sterile …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Genomic diversity of severe acute respiratory syndrome–coronavirus 2 in patients with coronavirus disease 2019

Z Shen, Y **ao, L Kang, W Ma, L Shi… - Clinical infectious …, 2020 - academic.oup.com
Background A novel coronavirus (CoV), severe acute respiratory syndrome (SARS)–CoV-2,
has infected> 75 000 individuals and spread to> 20 countries. It is still unclear how fast the …

Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions

Z Yan, B Chen, Y Yang, X Yi, M Wei… - Nature …, 2022 - nature.com
The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease
(COPD) remains largely unexplored. We present a landscape of airway microbe–host …

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

SA Kerk, T Papagiannakopoulos, YM Shah… - Nature Reviews …, 2021 - nature.com
Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

The influence of the microbiome on respiratory health

TP Wypych, LC Wickramasinghe, BJ Marsland - Nature immunology, 2019 - nature.com
The revolution in microbiota research over the past decade has provided invaluable
knowledge about the function of the microbial species that inhabit the human body. It has …

Aspiration pneumonia

LA Mandell, MS Niederman - New England Journal of Medicine, 2019 - Mass Medical Soc
Aspiration Pneumonia | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

The role of lung and gut microbiota in the pathology of asthma

W Barcik, RCT Boutin, M Sokolowska, BB Finlay - Immunity, 2020 - cell.com
Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

Lower airway dysbiosis affects lung cancer progression

JCJ Tsay, BG Wu, I Sulaiman, K Gershner, R Schluger… - Cancer discovery, 2021 - AACR
In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly
occurs, and ex vivo models support that some of these bacteria can trigger host …

The lung microbiome: progress and promise

SA Whiteside, JE McGinniss… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
The healthy lung was long thought of as sterile, but recent advances using molecular
sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely …