Nanoparticles as drug delivery carriers have benefited diseases, including cancer, since the
1990s, and more recently, their promise to quickly and efficiently be mobilized to fight …

Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following
injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and …

Human pluripotent stem cell-derived kidney organoids offer unprecedented opportunities for
studying polycystic kidney disease (PKD), which still has no effective cure. Here, we …

Kidney organoids derived from human pluripotent stem cells (hPSCs) are now being used
as models of renal disease and nephrotoxicity screening. However, the proximal tubules …

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …

A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …

Polycystic kidney diseases (PKDs) are genetic disorders characterized by the formation and
expansion of numerous fluid-filled renal cysts, damaging normal parenchyma and often …

The rising prevalence of kidney diseases urges the need for novel therapies. Kidney
organoids and tubuloids are advanced in vitro models and have recently been described as …

Recreating human tissues and organs in the petri dish to establish models as tools in
biomedical sciences has gained momentum. These models can provide insight into …