The role of ROS in tumour development and progression

EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

YA Hajam, R Rani, SY Ganie, TA Sheikh, D Javaid… - Cells, 2022 - mdpi.com
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology

A Vermot, I Petit-Härtlein, SME Smith, F Fieschi - Antioxidants, 2021 - mdpi.com
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Oxidative stress in atherosclerosis

AJ Kattoor, NVK Pothineni, D Palagiri… - Current atherosclerosis …, 2017 - Springer
Abstract Purpose of Review Atherosclerosis is now considered a chronic inflammatory
disease. Oxidative stress induced by generation of excess reactive oxygen species has …

Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

U Förstermann, N **a, H Li - Circulation research, 2017 - Am Heart Assoc
Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Mitochondrial dysfunction and oxidative stress in heart disease

JN Peoples, A Saraf, N Ghazal, TT Pham… - … & molecular medicine, 2019 - nature.com
Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection

S Cadenas - Free Radical Biology and Medicine, 2018 - Elsevier
Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …

Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets

Z Zhang, L Zhao, X Zhou, X Meng, X Zhou - Frontiers in immunology, 2023 - frontiersin.org
Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …