Sickle cell disease is caused by an abnormality of the β-globin gene and is characterised by
sickling of the red blood cells. Globally, sub-Saharan African countries share the highest …

Sickle cell disease (SCD) is the most common life-threatening monogenic disorder in the
world. The disease is highly prevalent in malaria endemic areas with over 75% of patients …

In Nigeria, about 150000 babies are born annually with sickle cell disease (SCD), and this
figure has been estimated to increase by 100% by the year 2050 without effective and …

Background Despite the proven efficacy of evidence-based healthcare interventions in
reducing adverse outcomes and mortality associated with Sickle Cell Disease (SCD), a vast …

Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr.
Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for …

Background Due to its severe adverse effect on child mortality, sickle cell disease (SCD) has
been identified as a set of diseases of public health concern. The high mortality rate among …

Sickle cell disease (SCD) is a genetic blood disorder in high prevalence in sub-Saharan
Africa (SSA) that leads to high morbidity and early mortality. Newborn screening (NBS) with …

Introduction Newborn Screening (NBS) is a public health program designed to identify and
provide early interventions for infants with genetic disorders such as Sickle Cell Disease …

Objective: Sickle cell disease (SCD) is a major genetic disease that occurs early in
childhood and can cause considerable morbidity and even death. Newborn screening …

The prevalence of sickle cell disease is high in Africa, with significant public health effects on
the affected countries. Many of the countries with the highest prevalence of the disease also …