Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Rationale: Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) are
increasingly being used for modeling heart disease and are under development for …

The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

Directed differentiation protocols enable derivation of cardiomyocytes from human
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Despite preclinical studies demonstrating the functional benefit of transplanting human
pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the …

The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …

Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

Transplantation studies in mice and rats have shown that human embryonic-stem-cell-
derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts,,, but two …