The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Osteoarthritis (OA) is one of the most common causes of disability around the globe,
especially in aging populations. The main symptoms of OA are pain and loss of motion and …

Painful degeneration of soft tissues accounts for high socioeconomic costs. Tissue
engineering aims to provide biomimetics recapitulating native tissues. Biocompatible …

Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …

Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …

The anatomic forms of diarthrodial joints are important structural features which provide and
limit the motions required for the joint. Typically, the length scale of topographic variation of …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

The extracellular matrix (ECM) may contribute to the drug resistance of a solid tumor by
preventing the penetration of therapeutic agents. We measured differences in interstitial …

Biodegradable scaffolds have played an important role in a number of tissue engineering
attempts over the past decade. The goal of this review article is to provide a brief overview of …

Emerging medical technologies for effective and lasting repair of articular cartilage include
delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue …