Strategies for the development of metalloimmunotherapies

X Sun, X Zhou, X Shi, OA Abed, X An, YL Lei… - Nature Biomedical …, 2024 - nature.com
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs
have a long record of accomplishment as effective treatments for a wide range of diseases …

Molecular mechanisms of calcium-induced membrane fusion

D Papahadjopoulos, S Nir, N Düzgünes - Journal of bioenergetics and …, 1990 - Springer
We have reviewed studies on calcium-induced fusion of lipid bilayer membranes and the
role of synexin and other calcium-binding proteins (annexins) in membrane fusion. We have …

Adsorption of divalent cations to bilayer membranes containing phosphatidylserine.

S McLAUGHLIN, N Mulrine, T Gresalfi, G Vaio… - The Journal of general …, 1981 - rupress.org
The Stern equation, a combination of the Langmuir adsorption isotherm, the Boltzmann
relation, and the Grahame equation from the theory of the diffuse double layer, provides a …

Studies on the mechanism of membrane fusion. Role of head-group composition in calcium-and magnesium-induced fusion of mixed phospholipid vesicles

N Düzgünes, J Wilschut, R Fraley… - … et Biophysica Acta (BBA …, 1981 - Elsevier
We have investigated the contribution of various phospholipids to membrane fusion induced
by divalent cations. Fusion was followed by means of a new fluorescence assay monitoring …

Electroformation of giant unilamellar vesicles on stainless steel electrodes

V Pereno, D Carugo, L Bau, E Sezgin… - ACS …, 2017 - ACS Publications
Giant unilamellar vesicles (GUVs) are well-established model systems for studying
membrane structure and dynamics. Electroformation, also referred to as electroswelling, is …

Role of calcium in the adhesion and fusion of bilayers

DE Leckband, CA Helm, J Israelachvili - Biochemistry, 1993 - ACS Publications
Role of calcium in the adhesion and fusion of bilayers Page 1 Biochemistry 1993, 32, 1127-1140
1127 Role of Calcium in the Adhesion and Fusion of Bilayers1- D. E. Leckband,1 C. A. Helm,§ …

Calcium-and magnesium-induced fusion of mixed phosphatidylserine/phosphatidylcholine vesicles: effect of ion binding

N Düzgüne §, S Nir, J Wilschut, J Bentz… - The Journal of …, 1981 - Springer
The aggregation, leakage, and fusion of pure PS (phosphatidylserine) and mixed PS/PC
(phosphatidylcholine) sonicated vesicles were studied by light scattering, the release of …

Influence of lipid composition and ionic strength on the physical stability of liposomes

DJA Crommelin - Journal of pharmaceutical sciences, 1984 - Elsevier
The effect of including charge-inducing agents (stearylamine or phosphatidylserine) on the
zeta potential of phosphatidylcholine-cholesterol-containing liposomes in aqueous media …

Study on the in situ aggregation of liposomes with negatively charged phospholipids for use as injectable depot formulation

L Rahnfeld, J Thamm, F Steiniger… - Colloids and Surfaces B …, 2018 - Elsevier
Compared to conventional parenteral formulations injectable depot formulations, owing to a
sustained drug release, offer several advantages, such as a reduced dosing frequency− and …

A mechanism of divalent ion-induced phosphatidylserine membrane fusion

S Ohki - Biochimica et Biophysica Acta (BBA)-Biomembranes, 1982 - Elsevier
A mechanism for the divalent cation-induced membrane fusion of phosphatidylserine
membranes is proposed. Fusion was followed by the Tb/DPA (dipicolinic acid) assay …