Kinetic models are critical to predict the dynamic behaviour of metabolic networks.
Mechanistic kinetic models for large networks remain uncommon due to the difficulty of fitting …

Dynamical systems describing whole cells are on the verge of becoming a reality. But as
models of reality, they are only useful if we have realistic parameters for the molecular …

In contrast to stoichiometric-based models, the development of large-scale kinetic models of
metabolism has been hindered by the challenge of identifying kinetic parameter values and …

Viable pollen is essential for plant reproduction and crop yield. Its production requires
coordinated expression at specific stages during anther development, involving early …

The key processes in biological and chemical systems are described by networks of
chemical reactions. From molecular biology to biotechnology applications, computational …

Highlights•Kinetic models are crucial to understand complex dynamic processes.•Not all
model parameters need to be known precisely due to overlap** regulatory …

Accurate determination of physiological states of cellular metabolism requires detailed
information about metabolic fluxes, metabolite concentrations and distribution of enzyme …

Background Many mathematical models have now been employed across every area of
systems biology. These models increasingly involve large numbers of unknown parameters …

Bacterial resistance to antibiotics: from molecules to man Bacterial Resistance to Antibiotics–From
Molecules to Man Page 2 Bacterial Resistance to Antibiotics–From Molecules to Man Edited …

Assigning molecular functions and revealing dynamic connections between large numbers
of partially characterized proteins in regulatory networks are challenges in systems biology …