High-throughput single-cell analysis of nanoparticle-cell interactions

M Haddad, AN Frickenstein, S Wilhelm - TrAC Trends in Analytical …, 2023 - Elsevier
Understanding nanoparticle-cell interactions at single-nanoparticle and single-cell
resolutions is crucial to improving the design of next-generation nanoparticles for safer …

Cellular journey of nanomaterials: Theories, trafficking, and kinetics

X Wang, WX Wang - Aggregate, 2023 - Wiley Online Library
Engineered nanomaterials (NMs) are increasingly fabricated in various fields involving
consumer goods, waste management, and biomedical applications such as drug delivery …

Quantifying intracellular nanoparticle distributions with three-dimensional super-resolution microscopy

V Sheth, X Chen, EM Mettenbrink, W Yang, MA Jones… - ACS …, 2023 - ACS Publications
Super-resolution microscopy can transform our understanding of nanoparticle–cell
interactions. Here, we established a super-resolution imaging technology to visualize …

Controlling nanoparticle uptake in innate immune cells with heparosan polysaccharides

W Yang, AN Frickenstein, V Sheth, A Holden… - Nano …, 2022 - ACS Publications
We used heparosan (HEP) polysaccharides for controlling nanoparticle delivery to innate
immune cells. Our results show that HEP-coated nanoparticles were endocytosed in a time …

Quantification of monodisperse and biocompatible gold nanoparticles by single-particle ICP-MS

AN Frickenstein, S Mukherjee, T Harcourt, Y He… - Analytical and …, 2023 - Springer
Bioanalytical and biomedical applications often require nanoparticles that exhibit narrow
size distributions and biocompatibility. Here, we demonstrate how different synthesis …

Gold nanoparticles disrupt the IGFBP2/mTOR/PTEN axis to inhibit ovarian cancer growth

MN Hossen, L Wang, SKD Dwivedi, Y Zhang… - Advanced …, 2022 - Wiley Online Library
By exploiting the self‐therapeutic properties of gold nanoparticles (GNPs) a molecular axis
that promotes the growth of high‐grade serous ovarian cancer (HGSOC), one of the …

Multi-omics approaches to decipher the interactions of nanoparticles and biological systems

Y Wang, Z **ao, Z Wang, DY Lee, Y Ma… - Nature Reviews …, 2024 - nature.com
Understanding how engineered nanoparticles interact with biological systems is crucial for
the development and implementation of nanoparticles in clinical settings. However …

Host-guest coupling to potentially increase the bio-accessibility of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by nanocarrier graphyne for brain tumor therapy, a …

AR Ayub, M Ilyas, N Hassan, K Irshad, M Zeshan… - Journal of Molecular …, 2023 - Elsevier
This study aimed to explore the potential of Host-Guest coupling with Nanocarrier graphyne
(GPH) to enhance the bioavailability of the drug 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea …

Single Cell Phenotypic Analysis for Cancer Stem Cell Identification by Dual-Isotope ICP-QMS

M Liu, X Wei, C Wu, J Liu, Y Wei, X Wang… - Analytical …, 2023 - ACS Publications
Single cell phenotypic analysis is significant for clinical diagnosis, treatment, and prognosis
of cancer. Accurate differentiation of cancer stem cell (CSC) subpopulations from a large …

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

R Clough, A Fisher, B Gibson, B Russell - Journal of Analytical Atomic …, 2023 - pubs.rsc.org
This update covers the literature published between approximately June 2022 and April
2023 and is the latest part of a series of annual reviews. It is designed to provide the reader …