Phase separation is emerging as a paradigm to explain the self-assembly and organization
of membraneless bodies in the cell. Recent advances show that this principle also extends …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

WHIRLIES are plant-specific proteins binding to DNA in plastids, mitochondria, and nucleus.
They have been identified as significant components of nucleoids in the organelles where …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

The advent of high-throughput sequencing-based methods for chromatin conformation,
accessibility, and immunoprecipitation assays has been a turning point in 3D genomics …

Develo** in silico models that accurately reflect a whole, functional cell is an ongoing
challenge in biology. Current efforts bring together mathematical models, probabilistic …

Mitochondria contain an autonomous and spatially segregated genome. The organizational
unit of their genome is the nucleoid, which consists of mitochondrial DNA (mtDNA) and …

Bacteria of the genus Streptomyces have a linear chromosome, with a core region and two
'arms'. During their complex life cycle, these bacteria develop multi-genomic hyphae that …

Nucleoid-associated proteins (NAPs) are crucial in organizing prokaryotic DNA and
regulating genes. Vital to these activities are complex nucleoprotein structures, however …

The histone‐like protein HU plays a diverse role in bacterial physiology from the
maintenance of chromosome structure to the regulation of gene transcription. HU binds DNA …