Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Background Following the discovery and emergence of the plasmid-mediated colistin
resistance gene, mcr-1, the Chinese government formally banned colistin as an animal …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

Summary Background TMexCD1-TOprJ1, which is associated with phenotypic resistance to
multiple classes of antibiotics, is a transmissible resistance-nodulation-division (RND) family …

The global burden of bacterial resistance remains one of the most serious public health
concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients …

Emergence of tigecycline-resistance tet (X) gene orthologues rendered tigecycline
ineffective as last-resort antibiotic. To understand the potential origin and transmission …

Klebsiella pneumoniae is considered an opportunistic pathogen, constituting an ongoing
health concern for immunocompromised patients, the elderly, and neonates. Reports on the …

With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise,
and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants …