Evolution of cancer pharmacological treatments at the turn of the third millennium
The medical history of cancer began millennia ago. Historical findings of patients with
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …
cancer date back to ancient Egyptian and Greek civilizations, where this disease was …
Molecular mechanisms of radiation-induced cancer cell death: a primer
Radiation therapy (RT) is responsible for at least 40% of cancer cures, however treatment
resistance remains a clinical problem. There have been recent advances in understanding …
resistance remains a clinical problem. There have been recent advances in understanding …
Tumor microenvironment as a “game changer” in cancer radiotherapy
M Jarosz-Biej, R Smolarczyk, T Cichoń… - International journal of …, 2019 - mdpi.com
Radiotherapy (RT), besides cancer cells, also affects the tumor microenvironment (TME):
tumor blood vessels and cells of the immune system. It damages endothelial cells and …
tumor blood vessels and cells of the immune system. It damages endothelial cells and …
The impact of radiation-induced DNA damage on cGAS-STING-mediated immune responses to cancer
Q Storozynsky, MM Hitt - International journal of molecular sciences, 2020 - mdpi.com
Radiotherapy is a major modality used to combat a wide range of cancers. Classical
radiobiology principles categorize ionizing radiation (IR) as a direct cytocidal therapeutic …
radiobiology principles categorize ionizing radiation (IR) as a direct cytocidal therapeutic …
Treatment of late sequelae after radiotherapy for head and neck cancer
Radiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head
and neck. Despite enormous advances in RT planning and delivery, a significant number of …
and neck. Despite enormous advances in RT planning and delivery, a significant number of …
Radiotherapy and immune response: the systemic effects of a local treatment
Technological developments have allowed improvements in radiotherapy delivery, with
higher precision and better sparing of normal tissue. For many years, it has been well known …
higher precision and better sparing of normal tissue. For many years, it has been well known …
Radiotherapy and the immune system: More than just immune suppression
Radiotherapy (RT) is still one of the standard cancer therapies, with up to two third of all
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …
[HTML][HTML] Medical gas plasma technology: Roadmap on cancer treatment and immunotherapy
S Bekeschus - Redox Biology, 2023 - Elsevier
Despite continuous therapeutic progress, cancer remains an often fatal disease. In the early
2010s, first evidence in rodent models suggested promising antitumor action of gas plasma …
2010s, first evidence in rodent models suggested promising antitumor action of gas plasma …
Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment
Y Muroyama, TR Nirschl, CM Kochel… - Cancer immunology …, 2017 - AACR
Radiotherapy (RT) enhances innate and adaptive antitumor immunity; however, the effects
of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor …
of radiation on suppressive immune cells, such as regulatory T cells (Treg), in the tumor …
Immunomodulation by ionizing radiation—impact for design of radio‐immunotherapies and for treatment of inflammatory diseases
Ionizing radiation is often regarded as an element of danger. But, danger responses on the
cellular and molecular level are often beneficial with regard to the induction of anti‐tumor …
cellular and molecular level are often beneficial with regard to the induction of anti‐tumor …