Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

Noise permeates biology on all levels, from the most basic molecular, sub-cellular
processes to the dynamics of tissues, organs, organisms and populations. The functional …

Most cells in our body communicate during development and throughout life via Notch
receptors and their ligands. Notch receptors relay information from the cell surface to the …

During development, cells undergo dramatic changes in their morphology. By affecting
contact geometry, these morphological changes could influence cellular communication …

A major goal of synthetic biology is to develop a deeper understanding of biological design
principles from the bottom up, by building circuits and studying their behavior in cells …

Self-organization is pervasive in development, from symmetry breaking in the early embryo
to tissue patterning and morphogenesis. For a few model systems, the underlying molecular …

Over the past decade, synthetic biology has emerged as an engineering discipline for
biological systems. Compared with other substrates, biology poses a unique set of …

Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides
regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the …

Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–
gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The …

Notch signaling pathway mediates cell-fate determination during embryonic development,
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …