Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Mutation accumulation in stem cells has been associated with cancer risk. However, the
presence of numerous mutant clones in healthy tissues has raised the question of what …

During their lifetimes, organisms acquire somatic mutations in individual cells caused by
genomic instability, endogenous DNA replication errors, or exposure to mutagens. When …

Somatic genetic variants have been studied for several years mostly concerning cancer,
where they contribute to its origin and development. It is also clear that the somatic variants …

Detection of somatic mutations in single cells has been severely hampered by technical
limitations of whole-genome amplification. Novel technologies including primary template …

Planarians are organisms with a unique capacity to regenerate any part of their body. New
tissues are generated in a process that requires many swift cell divisions. How costly is this …

Mutations accumulate in the genome of every cell of the body throughout life, causing
cancer and other genetic diseases1–4. Almost all of these mosaic mutations begin as …

Somatic clonal expansion refers to the proliferation and expansion of a cell clone within a
multicellular organism. Since cancer also results from the uncontrolled proliferation of few …

Monozygotic (MZ) twins originate from a single fertilized egg, making them genetically
identical at the time of conception. However, postzygotic somatic mutations (PZMs) can …

Aim Schizophrenia (SZ) is a severe psychiatric disorder caused by the interaction of genetic
and environmental factors. Although somatic mutations that occur in the brain after …