Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases

Y Han, Q Shang, J Yao, Y Ji - Cell Death & Disease, 2019 - nature.com
Hydrogen sulfide (H2S) serves as a gasotransmitter in the regulation of organ development
and maintenance of homeostasis in tissues. Its abnormal levels are associated with multiple …

Hydrogen sulfide and its role in female reproduction

A Pilsova, Z Pilsova, B Klusackova… - Frontiers in Veterinary …, 2024 - frontiersin.org
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three
enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3 …

Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and …

K Módis, P Panopoulos, C Coletta… - Biochemical …, 2013 - Elsevier
Although hydrogen sulfide (H 2 S) is generally known as a mitochondrial poison, recent
studies show that lower concentrations of H 2 S play a physiological role in the stimulation of …

[HTML][HTML] Neuroprotective Actions of Hydrogen Sulfide-Releasing Compounds in Isolated Bovine Retinae

L Bush, J Robinson, A Okolie, F Muili, CA Opere… - Pharmaceuticals, 2024 - mdpi.com
Background: We have evidence that hydrogen sulfide (H2S)-releasing compounds can
reduce intraocular pressure in normotensive and glaucomatous rabbits by increasing the …

The role of hydrogen sulfide in cyclic nucleotide signaling

X Cao, Z Wu, S **ong, L Cao, G Sethi, J Bian - Biochemical Pharmacology, 2018 - Elsevier
Hydrogen sulfide (H 2 S) is recognized as an endogenous gaseous transmitter alongside
nitric oxide (NO) and carbon monoxide (CO). By integrating into multiple signaling pathways …

Effect of hydrogen sulfide donors on intraocular pressure in rabbits

A Salvi, P Bankhele, J Jamil, MK Chitnis… - Journal of Ocular …, 2016 - liebertpub.com
Purpose: In this study, we investigated the effect of a slow-releasing hydrogen sulfide (H2S)
donor, GYY 4137, on intraocular pressure (IOP) in normotensive rabbits. Furthermore, we …

Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery

MK Chitnis, YF Njie-Mbye, CA Opere, ME Wood… - Experimental eye …, 2013 - Elsevier
Abstract Hydrogen sulfide (H 2 S), a colorless gas characterized by its pungent odor of rotten
eggs has been reported to elicit relaxation effects on basal and pre-contracted non-ocular …

Pharmacological actions of hydrogen sulfide donors on sympathetic neurotransmission in the bovine anterior uvea, in vitro

A Salvi, P Bankhele, JM Jamil, M Kulkarni-Chitnis… - Neurochemical …, 2016 - Springer
In the present study, we investigated the effect of three different sources of hydrogen sulfide
(H 2 S) on sympathetic neurotransmission from isolated superfused bovine iris-ciliary …

Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries

M Kulkarni-Chitnis, YF Njie-Mbye, L Mitchell… - Experimental eye …, 2015 - Elsevier
In the present study, we investigate the inhibitory effect of novel H 2 S donors, AP67 and
AP72 on isolated bovine posterior ciliary arteries (PCAs) under conditions of tone induced …

Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway

HY Yang, ZY Wu, M Wood, M Whiteman… - Antioxidants & redox …, 2014 - liebertpub.com
Aims: The best-established mechanism of opioid dependence is the up-regulation of
adenylate cyclase (AC)/cAMP pathway, which was reported to be negatively regulated by …