DNA nanotechnology has now enabled the self-assembly of almost any prescribed 3-
dimensional nanoscale structure in large numbers and with high fidelity. These structures …

The alternating-laser excitation (ALEX) scheme continues to expand the possibilities of
fluorescence-based assays to study biological entities and interactions. Especially the …

Amyloid β-peptide oligomer (AβO) is widely acknowledged as the promising biomarker for
the diagnosis of Alzheimer's disease (AD). In this work, we designed a three-dimensional …

Highlights•We review the walking principles for DNA based synthetic molecular walkers.•We
discuss characterization methods suitable for probing individual DNA walkers.•We evaluate …

Sensing nucleic acids typically involves the recognition of a specific sequence and reporting
by, for example, a fluorogenic reaction yielding one activated dye molecule per detected …

DNA has enormous potential as a programmable material for creating artificial nanoscale
structures and devices. For more complex systems, however, rational design and …

While numerous DNA-based molecular machines have been developed in recent years,
high operational yield and speed remain a major challenge. To understand the reasons for …

Allostery is a pervasive principle to regulate protein function. Growing evidence suggests
that also DNA is capable of transmitting allosteric signals. Yet, whether and how DNA …

DNA nanotechnology is a powerful and promising tool for the development of nanoscale
devices for numerous and diverse applications. One of the greatest potential fields of …

In this work, the successful operation of a dynamic DNA device constructed from two DNA
origami building blocks is reported. The device includes a bipedal walker that strides back …