Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …

P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the
body and is responsible for limiting cellular uptake and the distribution of xenobiotics and …

Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1
gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …

Drug efflux pumps like P-glycoprotein (P-gp) and multidrug resistance (MDR) proteins were
recognized to posses functional role in determining the pharmacokinetics of drugs …

The development of multidrug resistance (MDR) is a major obstacle in the chemotherapeutic
treatment of many human cancers, including colon, kidney and breast carcinomas …

The development of drug resistance continues to be a dominant hindrance toward curative
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …

Flavonoids are constituents of fruits, vegetables, and plant-derived beverages, as well as
components in herbal-containing dietary supplements. The objective of this investigation …

Efflux pump (eg, P-gp, MRP1, and BCRP) inhibition has been recognized as a strategy to
overcome multi-drug resistance and improve drug bioavailability. Besides small-molecule …