Point‐of‐care testing in haemostasis

DJ Perry, DA Fitzmaurice, S Kitchen… - British Journal of …, 2010 - Wiley Online Library
Point‐of‐care testing (POCT) in haematology has seen a significant increase in both the
spectrum of tests available and the number of tests performed annually. POCT is frequently …

The GPIIb/IIIa (integrin αIIbβ3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

BS Coller, SJ Shattil - Blood, The Journal of the American …, 2008 - ashpublications.org
Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

Guidelines for the laboratory investigation of heritable disorders of platelet function

P Harrison, I Mackie, A Mumford… - British journal of …, 2011 - Wiley Online Library
The guideline writing group was selected to be representative of UK‐based medical experts.
MEDLINE was systematically searched for publications in English up to the Summer of 2010 …

Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of …

W Kuliczkowski, A Witkowski, L Polonski… - European heart …, 2009 - academic.oup.com
Oral antiplatelet drugs are a cornerstone of modern pharmacotherapy in cardiovascular
atherothrombotic diseases. The efficacy of acetylsalicylic acid (ASA, aspirin) and clopidogrel …

Methods for the measurement of platelet function

AD Michelson - The American journal of cardiology, 2009 - Elsevier
This article discusses the advantages and disadvantages of methods for the measurement
of platelet function. The focus is on tests that can be used to monitor antiplatelet activity in …

Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial

AD Michelson, AL Frelinger III, E Braunwald… - European heart …, 2009 - academic.oup.com
Aims To examine the extent of platelet inhibition by prasugrel vs. clopidogrel in a TRITON-
TIMI 38 substudy. Methods and results TRITON-TIMI 38 randomized acute coronary …

Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response

S Le Quellec, JC Bordet, C Negrier… - Thrombosis and …, 2016 - thieme-connect.com
The two most widely used antiplatelet drugs in the world are aspirin and clopidogrel.
However, some patients on aspirin and/or clopidogrel therapy do not respond appropriately …

Chronic kidney disease is associated with increased platelet activation and poor response to antiplatelet therapy

T Gremmel, M Müller, S Steiner… - Nephrology Dialysis …, 2013 - academic.oup.com
Background Chronic kidney disease (CKD) is a common co-morbidity of patients with
atherosclerotic vascular disease, and may influence the response to antiplatelet therapy …

[HTML][HTML] Different methodologies for evaluating the effect of clopidogrel on platelet function in high‐risk coronary artery disease patients

R Paniccia, E Antonucci, AM Gori, R Marcucci… - Journal of Thrombosis …, 2007 - Elsevier
Background: Two point‐of‐care (POC) systems have been recently proposed as rapid tools
with which to evaluate residual platelet reactivity (RPR) in coronary artery disease (CAD) …

Antiplatelet actions of statins and fibrates are mediated by PPARs

FY Ali, PCJ Armstrong, ARA Dhanji… - … , and vascular biology, 2009 - Am Heart Assoc
Objectives—Statins and fibrates are hypolipidemic drugs which decrease cardiac events in
individuals without raised levels of cholesterol. These drugs inhibit platelet function, but the …