The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …

This Perspective is a continuation of our analysis of US FDA-approved small-molecule drugs
(1938–2012) containing nitrogen heterocycles. In this study we report drug structure and …

In the present review, we discuss recent progress in the field of C–Z bond formation
reactions (Z= S, Se, Te) catalyzed by transition metals. Two complementary methodologies …

Catalytic C (sp3)–H functionalization has provided enormous opportunities to construct
organic molecules, facilitating the derivatization of complex pharmaceutical compounds …

In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

The production of elemental sulfur from petroleum refining has created a technological
opportunity to increase the valorization of elemental sulfur by the synthesis of high …

Sulfinates are important lynchpin intermediates in pharmaceutical production; however, their
synthesis via photoredox catalysis is challenging because of their facile oxidation. We …

Phenols and phenolic ethers are significant scaffolds recurring both in nature and among
approved small-molecule pharmaceuticals. This compendium presents the first …