Long-distance microbial mechanisms impacting cancer immunosurveillance
The intestinal microbiota determines immune responses against extraintestinal antigens,
including tumor-associated antigens. Indeed, depletion or gross perturbation of the …
including tumor-associated antigens. Indeed, depletion or gross perturbation of the …
Emerging chemophysiological diversity of gut microbiota metabolites
X Lin, K He, Z Gu, X Zhao - Trends in Pharmacological Sciences, 2024 - cell.com
Human physiology is profoundly influenced by the gut microbiota, which generates a wide
array of metabolites. These microbiota-derived compounds serve as signaling molecules …
array of metabolites. These microbiota-derived compounds serve as signaling molecules …
Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions
H Zhang, Y **e, F Cao, X Song - Gut microbes, 2024 - Taylor & Francis
Commensal microorganisms in the human gut produce numerous metabolites by using
small molecules derived from the host or diet as precursors. Host or dietary lipid molecules …
small molecules derived from the host or diet as precursors. Host or dietary lipid molecules …
TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing
C Li, L Wang, W **e, E Chen, Y Chen, H Li, D Can… - Science …, 2024 - science.org
Bile acids (BAs) metabolism has a significant impact on the pathogenesis of Alzheimer's
disease (AD). We found that deoxycholic acid (DCA) increased in brains of AD mice at an …
disease (AD). We found that deoxycholic acid (DCA) increased in brains of AD mice at an …
Intestinal Lactobacillus murinus-derived small RNAs target porcine polyamine metabolism
L Fan, B Liu, Y Wang, B Tang, T Xu, J Fu… - Proceedings of the …, 2024 - pnas.org
Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes
on polyamine metabolism is unknown. Here, we found germ-free models possess elevated …
on polyamine metabolism is unknown. Here, we found germ-free models possess elevated …
Bile acid signaling in metabolic and inflammatory diseases and drug development
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …
Gut microbial metabolites in cancer therapy
P Song, Z Peng, X Guo - Trends in Endocrinology & Metabolism, 2024 - cell.com
The gut microbiota plays a crucial role in maintaining homeostasis and promoting health. A
growing number of studies have indicated that gut microbiota can affect cancer …
growing number of studies have indicated that gut microbiota can affect cancer …
A probiotic Limosilactobacillus fermentum GR-3 mitigates colitis-associated tumorigenesis in mice via modulating gut microbiome
Bacterial therapy for colorectal cancer (CRC) represents a burgeoning frontier. The probiotic
Limosilactobacillus fermentum GR-3, derived from traditional food “Jiangshui”, exhibited …
Limosilactobacillus fermentum GR-3, derived from traditional food “Jiangshui”, exhibited …
[HTML][HTML] Biological functions and pharmacological behaviors of bile acids in metabolic diseases
T Zhuang, X Wang, Z Wang, L Gu, D Yue… - Journal of Advanced …, 2024 - Elsevier
Abstract Background Bile acids (BAs), synthesized endogenously from cholesterol, play a
central role in metabolic regulation within the enterohepatic circulatory system. Traditionally …
central role in metabolic regulation within the enterohepatic circulatory system. Traditionally …
Fecal microbial transplants as investigative tools in cancer
The gut microbiome plays a critical role in the development, progression, and treatment of
cancer. As interest in microbiome-immune-cancer interactions expands, the prevalence of …
cancer. As interest in microbiome-immune-cancer interactions expands, the prevalence of …