Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

Background This narrative review aims to discuss several common neurological and
psychiatric disorders that show comorbidity with migraine. Not only can we gain …

Acute sleep deprivation is a common condition in modern life and increases anxiety
symptoms in healthy individuals. The neuroinflammatory response induced by microglial …

One year after the outbreak of coronavirus disease 2019 (COVID‐19), referrals for persistent
headache, often defined as “post‐COVID headache,” have become increasingly common in …

Background and aims Cortical spreading depression (CSD), a transient neuronal and glial
depolarization that propagates slowly across the cerebral cortex, is the putative …

The individual and global burden of migraine is of such significance that there are
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …

Epidemiological estimates indicate that individuals with epilepsy are more likely to
experience headaches, including migraine, than individuals without epilepsy. Headaches …

Cortical spreading depression or CSD is an electrophysiological phenomenon affecting
various perspectives of brain physiology such as ionic balance, neurotransmitter level, and …

Migraine is indeed a neurovascular disorder for which several genes have been identified in
this era of Genome-Wide Association Studies (GWAS) and neuroimaging studies have …

Abstract Background and Purpose Headache disorders place a significant burden on the
healthcare system, being the leading cause of disability in those under 50 years. Novel …