Vaccines have proven effective in the treatment and prevention of numerous diseases.
However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such …

The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …

Chagas disease is currently endemic to 21 Latin-American countries and has also become a
global concern because of globalization and mass migration of chronically infected …

Chagas disease is a major neglected tropical disease, transmitted predominantly by
triatomine insect vectors, but also through congenital and oral routes. While endemic in the …

In recent years, tattooing technology has shown promising results toward evaluating
vaccines in both animal models and humans. However, this technology has some limitations …

Phase 1 clinical trials with a DNA vaccine for dengue demonstrated that the vaccine is safe
and well tolerated, however it produced less than optimal humoral immune responses. To …

Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21
Latin American countries and the southern United States and now is spreading into several …

Chagas disease is a chronic and potentially lethal disorder caused by the parasite
Trypanosoma cruzi, and an effective treatment has not been developed for chronic Chagas …

Sarcocystis spp. are coccidian protozoans belonging to the Apicomplexa phylum. As with
other members of this phylum, they are obligate intracellular parasites with complex cellular …