Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …

Despite impressive recent establishment of therapeutic nucleic acids as drugs and vaccines,
their broader medical use is impaired by modest performance in intracellular delivery …

Carriers for RNA delivery must be dynamic, first stabilizing and protecting therapeutic RNA
during delivery to the target tissue and across cellular membrane barriers and then …

The blood-brain barrier (BBB) is a highly selective biological barrier that represents a major
bottleneck in the treatment of all types of central nervous system (CNS) disorders. Small …

Polymers used for the delivery of nucleic acids (NAs) typically possess ionizable, cationic
moieties enabling their electrostatic interactions with negatively charged NAs and form …

Rational design is pivotal in the modern development of nucleic acid nanocarrier systems.
With the rising prominence of polymeric materials as alternatives to lipid-based carriers …

Cationic polymers are known to efficiently deliver nucleic acids to target cells by
encapsulating the cargo into nanoparticles. However, the molecular organization of these …

Nucleic acid delivery with mRNA lipid nanoparticles are being developed for targeting a
wide array of tissues and cell types. However, targeted delivery to the bone …

The rise of biologics and RNA-based therapies challenges the limitations of traditional drug
treatments. However, these potent new classes of therapeutics require effective delivery …

Genome editing technologies have been key to unlocking new bioengineering strategies as
they enable the modification of mammalian cells' genes in a fully user-programmed mode …