Population geneticists have long sought to understand the contribution of natural selection
to molecular evolution. A variety of approaches have been proposed that use population …

Molecular population genetics aims to explain genetic variation and molecular evolution
from population genetics principles. The field was born 50 years ago with the first measures …

Structural variants (SVs) are a largely unexplored feature of plant genomes. Little is known
about the type and size of SVs, their distribution among individuals and, especially, their …

The distribution of fitness effects (DFE) encompasses the fraction of deleterious, neutral, and
beneficial mutations. It conditions the evolutionary trajectory of populations, as well as the …

As both natural selection and population history can affect genome-wide patterns of
variation, disentangling the contributions of each has remained as a major challenge in …

African apes harbor at least twelve Plasmodium species, some of which have been a source
of human infection. It is now well established that Plasmodium falciparum emerged following …

It is known that the allele ancestral to the variation at a polymorphic site cannot be assigned
with certainty, and that the most frequently used method to assign the ancestral state …

Upstream open reading frames (uORFs) play important roles in regulating the main coding
DNA sequences (CDSs) via translational repression. Despite their prevalence in the …

Many SNPs are predicted to encode deleterious amino acid variants. These slightly
deleterious mutations can provide unique insights into population history, the dynamics of …

Wild-living African apes are endemically infected with parasites that are closely related to
human Plasmodium vivax, a leading cause of malaria outside Africa. This finding suggests …