Nuclear receptors have a broad spectrum of biological functions in normal physiology and in
the pathology of various diseases, including glomerular disease. The primary therapies for …

Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …

Arctigenin (ATG) is a major component of Fructus Arctii, a traditional herbal remedy that
reduced proteinuria in diabetic patients. However, whether ATG specifically provides …

Introduction Currently, revealing how to prevent and control hyperuricemia has become an
essential public health issue. Sulforaphane has a wide range of applications in the …

Podocytes form the backbone of the glomerular filtration barrier and are exposed to various
mechanical forces throughout the lifetime of an individual. The highly dynamic …

Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI)
treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System …

The glomerulus is a compact cluster of capillaries responsible for blood filtration and
initiating urine production in the renal nephrons. A trilaminar structure in the capillary wall …

Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …

Podocytes are terminally differentiated cells of the kidney filtration barrier. They are
subjected to physiological filtration pressure and considerable mechanical strain, which can …

To understand complex diseases, high-throughput data are generated at large and multiple
levels. However, extracting meaningful information from large datasets for comprehensive …