Fusion peptides comprise conserved hydrophobic domains absolutely required for the
fusogenic activity of glycoproteins from divergent virus families. After 30 years of intensive …

Human immunodeficiency virus type 1 (HIV-1), the pathogen of acquired immunodeficiency
syndrome (AIDS), causes∼ 2 millions death every year and still defies an effective vaccine …

SARS‐CoV‐2 may enter target cells through the process of membrane fusion at either the
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …

To rationalize the antiviral actions of plant alkaloids, the ability of 20 compounds to inhibit
calcium-mediated fusion of lipid vesicles composed of phosphatidylglycerol and cholesterol …

Influenza virus is one of the most devastating human pathogens. In order to infect host cells,
this virus fuses its membrane with the host membrane in a process mediated by the …

Membrane fusion and fission are two key processes that occur during the replication of
enveloped viruses, namely access to the interior of the host-cell (entry, which requires fusion …

To better understand peptide-induced membrane fusion at a molecular level, we set out to
determine the structure of the fusogenic peptide FP23 from the HIV-1 protein gp41 when …

It is possible that a defined curvature at the membrane interface controls its pH/polarity to
exhibit specific bioactivity. By utilizing an interface-interacting spiro-rhodamine pH probe …

The HIV-1 fusion peptide, which is a short hydrophobic peptide from the gp41 coat
glycoprotein that participates in the infection of a cell, interacts with model lipid bilayer …

Lipid composition of viral envelopes is usually rich in sphingolipids and cholesterol (CHOL).
These components have a stiffening effect on the membrane, thus enhancing the energetic …