Identity by descent: variation in meiosis, across genomes, and in populations

EA Thompson - Genetics, 2013 - academic.oup.com
Gene identity by descent (IBD) is a fundamental concept that underlies genetically mediated
similarities among relatives. Gene IBD is traced through ancestral meioses and is defined …

Linkage disequilibrium and association studies in higher plants: present status and future prospects

PK Gupta, S Rustgi, PL Kulwal - Plant molecular biology, 2005 - Springer
During the last two decades, DNA-based molecular markers have been extensively utilized
for a variety of studies in both plant and animal systems. One of the major uses of these …

Score tests for association between traits and haplotypes when linkage phase is ambiguous

DJ Schaid, CM Rowland, DE Tines… - The American Journal of …, 2002 - cell.com
A key step toward the discovery of a gene related to a trait is the finding of an association
between the trait and one or more haplotypes. Haplotype analyses can also provide critical …

Association study designs for complex diseases

LR Cardon, JI Bell - Nature Reviews Genetics, 2001 - nature.com
Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

Genomewide association studies: history, rationale, and prospects for psychiatric disorders

Psychiatric GWAS Consortium … - American Journal of …, 2009 - psychiatryonline.org
Objective: The authors conducted a review of the history and empirical basis of genomewide
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …

Haplotypes vs single marker linkage disequilibrium tests: what do we gain?

J Akey, L **, M ** complex traits
L Peltonen, A Palotie, K Lange - Nature Reviews Genetics, 2000 - nature.com
Geneticists have repeatedly turned to population isolates for map** and cloning
Mendelian disease genes. Population isolates possess many advantages in this regard …

The genetics of phenylthiocarbamide perception

SW Guo, DR Reed - Annals of human biology, 2001 - Taylor & Francis
The ability to taste the bitter compound phenylthiocarbamide (PTC) and related chemicals is
bimodal, and all human populations tested to date contain some people who can and some …

[KNYGA][B] Genetic Resources, Chromosome Engineering, and Crop Improvement: Cereals, Volume 2

RJ Singh, PP Jauhar - 2006 - taylorfrancis.com
Summarizing landmark research, Volume 2 of this essential series furnishes information on
the availability of germplasm resources that breeders can exploit for producing high-yielding …

Linkage disequilibrium and the search for complex disease genes

LB Jorde - Genome research, 2000 - genome.cshlp.org
During the past two decades, linkage analysis has been phenomenally successful in
localizing Mendelian disease genes. Linkage disequilibrium (LD) analysis, which effectively …