Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis
Background Several studies and meta-analyses have shown that mortality in people with
schizophrenia is higher than that in the general population but have used relative measures …
schizophrenia is higher than that in the general population but have used relative measures …
Develo** and evaluating polygenic risk prediction models for stratified disease prevention
Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …
accordance with recent events, such as discoveries of large numbers of disease …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
An atlas of genetic correlations across human diseases and traits
Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …
etiological insights and help prioritize likely causal relationships. The major challenges …
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders are likely to converge on
biological pathways influencing the development and maintenance of brain structure and …
biological pathways influencing the development and maintenance of brain structure and …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …
incidence and prevalence of dementia increases, and the need to understand the etiology …
Impact of psychotropic medication effects on obesity and the metabolic syndrome in people with serious mental illness
People with serious mental illness (SMI), including schizophrenia, bipolar disorder, and
major depressive disorder, have a higher mortality rate and shortened life expectancy. This …
major depressive disorder, have a higher mortality rate and shortened life expectancy. This …
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …
cognitive impairment, which is considered a major determinant of functional outcome …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …