[HTML][HTML] Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds
G Zhu, T Zhang, M Chen, K Yao, X Huang, B Zhang… - Bioactive materials, 2021 - Elsevier
Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …
approaches, autologous and allogeneic bone grafting have not achieved the ideal …
Review of signaling pathways governing MSC osteogenic and adipogenic differentiation
AW James - Scientifica, 2013 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
Mechanical forces are fundamental regulators of cell behaviors. However, molecular
regulation of mechanotransduction remain poorly understood. Here, we identified the …
regulation of mechanotransduction remain poorly understood. Here, we identified the …
Mechanical regulation of mesenchymal stem cell differentiation
Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …
[HTML][HTML] Omega-3 fatty acids activate ciliary FFAR4 to control adipogenesis
KI Hilgendorf, CT Johnson, A Mezger, SL Rice… - Cell, 2019 - cell.com
Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory
organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular …
organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular …
Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and …
Mesenchymal stem cells (MSCs) hold great potential for regenerative medicine and tissue-
engineering applications. They have multipotent differentiation capabilities and have been …
engineering applications. They have multipotent differentiation capabilities and have been …
Mechanical Stress Regulates Osteogenesis and Adipogenesis of Rat Mesenchymal Stem Cells through PI3K/Akt/GSK‐3β/β‐Catenin Signaling Pathway
F Song, D Jiang, T Wang, Y Wang… - BioMed research …, 2017 - Wiley Online Library
Osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) are
regarded as being of great importance in the regulation of bone remodeling. In this study, rat …
regarded as being of great importance in the regulation of bone remodeling. In this study, rat …
The effects of dynamic loading on the intervertebral disc
Loading is important to maintain the balance of matrix turnover in the intervertebral disc
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …
A concert between biology and biomechanics: the influence of the mechanical environment on bone healing
In order to achieve consistent and predictable fracture healing, a broad spectrum of growth
factors are required to interact with one another in a highly organized response. Critically …
factors are required to interact with one another in a highly organized response. Critically …
A perspective on the physical, mechanical and biological specifications of bioinks and the development of functional tissues in 3D bioprinting
Bioinks are the basic building blocks for the fabrication of 3D bioprinted constructs. These
bioinks play key roles in structural support, adhesion, and differentiation of incorporated …
bioinks play key roles in structural support, adhesion, and differentiation of incorporated …