ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …

MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …

Immune response to disease requires coordinated expression of an army of molecules. The
highly polymorphic MHC class I and class II molecules are key to control of specificity of …

Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide
loading complex plays a critical role in antigen presentation and immune recognition …

In mammalian cells, nearly one-third of proteins are inserted into the endoplasmic reticulum
(ER), where they undergo oxidative folding and chaperoning assisted by approximately 20 …

The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions
in the genomes of vertebrates. In the human population, thousands of MHC gene variants …

Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in
the absence of tapasin, an essential component of the peptide loading complex. We …

ATP-binding cassette (ABC) transporters are found in all domains of life and constitute one
of the largest protein superfamilies. ABC transporters harness the energy of ATP binding …

Major histocompatibility complex class I (MHC I) molecules are central to adaptive immunity.
Their assembly, epitope selection, and antigen presentation are controlled by the MHC I …