Artificial intelligence and machine learning for protein toxicity prediction using proteomics data

S Vishnoi, H Matre, P Garg… - Chemical Biology & Drug …, 2020 - Wiley Online Library
Instead of only focusing on the targeted drug delivery system, researchers have a great
interest in develo** peptide‐based therapies for the procurement of numerous class of …

MathFeature: feature extraction package for DNA, RNA and protein sequences based on mathematical descriptors

RP Bonidia, DS Domingues, DS Sanches… - Briefings in …, 2022 - academic.oup.com
One of the main challenges in applying machine learning algorithms to biological sequence
data is how to numerically represent a sequence in a numeric input vector. Feature …

Amino acid composition in various types of nucleic acid-binding proteins

M Bartas, J Červeň, S Guziurová, K Slychko… - International Journal of …, 2021 - mdpi.com
Nucleic acid-binding proteins are traditionally divided into two categories: With the ability to
bind DNA or RNA. In the light of new knowledge, such categorizing should be overcome …

Prediction for understanding the effectiveness of antiviral peptides

A Nath - Computational Biology and Chemistry, 2021 - Elsevier
The low efficacy of current antivirals in conjunction with the resistance of viruses against
existing antiviral drugs has resulted in the demand for the development of novel antiviral …

How can artificial intelligence be used for peptidomics?

L Perpetuo, J Klein, R Ferreira, S Guedes… - Expert Review of …, 2021 - Taylor & Francis
Introduction Peptidomics is an emerging field of omics sciences using advanced isolation,
analysis, and computational techniques that enable qualitative and quantitative analyses of …

Use Chou's 5-steps rule to predict remote homology proteins by merging grey incidence analysis and domain similarity analysis

W Lin, X **ao, W Qiu, KC Chou - Natural Science, 2020 - archive.jibiology.com
Detecting remote homology proteins is a challenging problem for both basic research and
drug development. Although there are a couple of methods to deal with this problem, the …

Gluconeogenesis unraveled: A proteomic Odyssey with machine learning

SA Khawaja, F Alturise, T Alkhalifah, SA Khan… - Methods, 2024 - Elsevier
The metabolic pathway known as gluconeogenesis, which produces glucose from non-
carbohydrate substrates, is essential for maintaining balanced blood sugar levels while …

Proposing 5-steps rule is a notable milestone for studying molecular biology

KC Chou - Natural Science, 2020 - article.researchpromo.com
In this current minireview, the cradle of the “5-steps rule” or “5-step rules”, along with its
essence and advances, has been recalled. Born in 2011, its impacts on molecular biology …

[HTML][HTML] Gaining insights into the physicochemical properties and sequence space of blood–brain barrier penetrating peptides

A Nath, S Pandey, KS Nisar, AK Tiwari - Egyptian Informatics Journal, 2024 - Elsevier
The blood–brain barrier (BBB) poses a significant obstacle to the administration of drugs to
the brain for the development of therapies of central nervous system (CNS) disorders. Blood …

[HTML][HTML] Other mountain stones can attack jade: the 5-steps rule

KC Chou - Natural Science, 2020 - scirp.org
Since the 5-steps rule was proposed in 2011, it has been widely used in many areas of
molecular biology, both theoretical and experimental. It can be even used to deal with the …