Microfluidic models of the neurovascular unit: a translational view

NR Wevers, HE De Vries - Fluids and Barriers of the CNS, 2023‏ - Springer
The vasculature of the brain consists of specialized endothelial cells that form a blood-brain
barrier (BBB). This barrier, in conjunction with supporting cell types, forms the neurovascular …

Synchronization between peripheral circadian clock and feeding-fasting cycles in microfluidic device sustains oscillatory pattern of transcriptome

O Gagliano, C Luni, Y Li, S Angiolillo, W Qin… - Nature …, 2021‏ - nature.com
The circadian system cyclically regulates many physiological and behavioral processes
within the day. Desynchronization between physiological and behavioral rhythms increases …

Towards biochemical microreactor: Nonlocal photovoltaic actuation of aqueous microdroplets in oil-infused PDMS channels based on LiNbO3: Fe crystal

M Wang, Z Gao, X Liu, L Shi, Y Mi, K Gao… - Sensors and Actuators B …, 2021‏ - Elsevier
Biocompatible, pump-free microfluidic actuation is a challenging task for optically integrated
lab-on-chips. Herein, photovoltaic actuation of aqueous microdroplets is demonstrated …

Parallel and large‐scale antitumor investigation using stable chemical gradient and heterotypic three‐dimensional tumor coculture in a multi‐layered microfluidic …

W Liu, R Hu, K Han, M Sun, D Liu… - Biotechnology …, 2021‏ - Wiley Online Library
Background Cancer has been responsible for a large number of human deaths in the 21st
century. Establishing a controllable, biomimetic, and large‐scale analytical platform to …

Straightforward neuron micropatterning and neuronal network construction on cell-repellent polydimethylsiloxane using microfluidics-guided functionalized Pluronic …

W Liu, W Fu, M Sun, K Han, R Hu, D Liu, J Wang - Analyst, 2021‏ - pubs.rsc.org
Neuronal cell microengineering involving micropatterning and polydimethylsiloxane (PDMS)
microfluidics enables promising advances in microscale neuron control. However, a facile …

Large-scale investigation of single cell activities and response dynamics in a microarray chip with a microfluidics-fabricated microporous membrane

K Han, M Sun, J Zhang, W Fu, R Hu, D Liu, W Liu - Analyst, 2021‏ - pubs.rsc.org
Microengineering technology involving microfabrication, micropatterning and microfluidics
enables promising advances in single cell manipulation and analysis. Herein, we describe a …

Toward new forms of particle sensing and manipulation and 3D imaging on a smartphone for healthcare applications

J Zhu, N Zhao, S Liu, S Wei… - Advanced Photonics …, 2022‏ - Wiley Online Library
Close to half of the world population have smartphones, while a flagship smartphone today
has been integrated with more than 20 smart components and sensors, making a …

Microfluidic models of the neurovascular unit

NR Wevers - 2021‏ - research.vu.nl
Need for novel models of the NVU Chapter 1, the general introduction, describes the need
for novel in vitro models of the human brain and its vasculature. Morphogens and the blood …