Neurodegenerative diseases (NDs) are currently incurable diseases that cause progressive
degeneration of nerve cells. Many of the disease-causing proteins of NDs are “undruggable” …

Targeting protein–protein interactions (PPIs) has become a common approach to tackle
various diseases whose pathobiology is driven by their mis-regulation in important …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial
cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of …

Stem cell senescence is an important cause of aging. Delaying senescence may present a
novel way to combat aging and age‐associated diseases. This study provided a mechanistic …

14-3-3 proteins are a family of proteins expressed throughout the body and implicated in
many diseases, from cancer to neurodegenerative disorders. While these proteins do not …

Breast cancer remains the most frequently diagnosed cancer in women worldwide. Tumors
that express hormone receptors account for 75% of all cases. Understanding alternative …

Breast cancer is one of the most frequent cancer types worldwide and the first cause of
cancer-related deaths in women. Although significant therapeutic advances have been …

The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed
without detrimental consequences to the organism. Liver regeneration is a complex process …

Fusicoccin is the α glucoside of a carbotricyclic diterpene, produced by the fungus
Phomopsis amygdali (previously classified as Fusicoccum amygdali), the causal agent of …