Review of the Geant4-DNA simulation toolkit for radiobiological applications at the cellular and DNA level

I Kyriakou, D Sakata, HN Tran, Y Perrot, WG Shin… - Cancers, 2021 - mdpi.com
Simple Summary A brief description of the methodologies to simulate ionizing radiation
transport in biologically relevant matter is presented. Emphasis is given to the physical …

Analysis and review of chemical reactions and transport processes in pulsed electrical discharge plasma formed directly in liquid water

BR Locke, SM Thagard - Plasma Chemistry and Plasma Processing, 2012 - Springer
Electrical discharges formed directly in liquid water include three general cases where (a)
streamer-like plasma channels form in, but do not span, the electrode gap,(b) spark …

TOPAS-nBio: an extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology

J Schuemann, AL McNamara… - Radiation …, 2019 - meridian.allenpress.com
The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …

LET-dependent intertrack yields in proton irradiation at ultra-high dose rates relevant for FLASH therapy

J Ramos-Méndez, N Domínguez-Kondo… - Radiation …, 2020 - meridian.allenpress.com
FLASH radiotherapy delivers a high dose (≥ 10 Gy) at a high rate (≥ 40 Gy/s). In this way,
particles are delivered in pulses as short as a few nanoseconds. At that rate, intertrack …

Independent reaction times method in Geant4‐DNA: Implementation and performance

J Ramos‐Méndez, W Shin, M Karamitros… - Medical …, 2020 - Wiley Online Library
Purpose The simulation of individual particle tracks and the chemical stage following water
radiolysis in biological tissue is an effective means of improving our knowledge of the …

TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation

J Ramos-Méndez, JA LaVerne… - Physics in Medicine …, 2021 - iopscience.iop.org
The chemical stage of the Monte Carlo track-structure simulation code Geant4-DNA has
been revised and validated. The root-mean-square (RMS) empirical parameter that dictates …

Stochastic simulation of the electron radiolysis of water and aqueous solutions

SM Pimblott, JA LaVerne - The Journal of Physical Chemistry A, 1997 - ACS Publications
Stochastic modeling of the radiolysis of water and of aqueous solutions employing simulated
track structures and the independent reaction times methodology is used to investigate the …

A review of simulation codes and approaches for radiation chemistry

I Plante - Physics in Medicine & Biology, 2021 - iopscience.iop.org
Historically, the field of radiation chemistry began shortly after the discovery of radioactivity,
and its development has been closely related to discoveries in other related fields such as …

Monte Carlo simulation of physicochemical processes of liquid water radiolysis: The effects of dissolved oxygen and OH scavenger

H Tomita, M Kai, T Kusama, A Ito - Radiation and environmental …, 1997 - Springer
The paper describes developments of the physicochemical part of a computer code system
that estimates DNA strand break induction on plasmid pBR322 DNA. In order to test the …

Validation and investigation of reactive species yields of Geant4‐DNA chemistry models

D Peukert, S Incerti, I Kempson, M Douglass… - Medical …, 2019 - Wiley Online Library
Purpose Indirect biological damage due to reactive species produced in water radiolysis
reactions is responsible for the majority of biological effect for low linear energy transfer …